I'm excited about MXML, and you should be too.
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If you don't have it, go get it!
Lin Lin's Tips for using Flex Builder 2.
There's great integration between MXML and Flex Enterprise Services. You can hook a listbox up to a data source and when the data source changes, that change is propagated all the way out to the listbox. It's a very cool infrastructure.
But sometimes you just want to hook up to an existing back end. Here's a good thread on the Macromedia forums with sample code posted by Mike Potter of Adobe.